De Vivo DC, Bohan TP, Coulter DL, et al. View abstract. Lisinopril (lisinipril) can cause nausea, headaches, anxiety, insomnia, drowsiness, nasal congestion and sexual dysfunction. Nutrition 2006;22(2):136-145. View abstract. 12761 Benvenga S, Amato A, Calvani M, Trimarchi F. Effects of carnitine on thyroid hormone action. Pande, S., Brion, L. P., Campbell, D. E., Gayle, Y., and Esteban-Cruciani, N. V. Lack of effect of L-carnitine supplementation on weight gain in very preterm infants. 1991;13(1-2):135-146. View abstract. Acta Europ Fertil 1992;23:221-4. View abstract. 2006;12(5):261-262. View abstract. View abstract. Amino.Acids 2012;42(5):1783-1792. Sarafoglou, K., Tridgell, A. H., Bentler, K., Redlinger-Grosse, K., Berry, S. A., and Schimmenti, L. A. Cardiac conduction improvement in two heterozygotes for primary carnitine deficiency on L-carnitine supplementation. Kolker, S., Garbade, S. F., Greenberg, C. R., Leonard, J. V., Saudubray, J. M., Ribes, A., Kalkanoglu, H. S., Lund, A. M., Merinero, B., Wajner, M., Troncoso, M., Williams, M., Walter, J. H., Campistol, J., Marti-Herrero, M., Caswill, M., Burlina, A. View abstract. View abstract. Dig Liver Dis 2007;39:922-8. Cherchi A, Lai C, Angelino F, et al. A vitamin/nutriceutical formulation improves memory and cognitive performance in community-dwelling adults without dementia. This was not something I was expecting. Clin Chim Acta 2005;360:173-7. Isidori, A. M., Pozza, C., Gianfrilli, D., and Isidori, A. Proc Assoc Am Physicians 1997;109:146-53. View abstract. 2007;22(6):330-337. Lster H, Miehe K, Punzel M, et al. Clin Ther 1995;17:176-85. As a supplement, acetyl-L-carnitine is usually considered safe when taken as directed. Latifian S, Hamdi K, Totakneh R. Effect of addition of l-carnitine in polycystic ovary syndrome (PCOS) patients with clomiphene citrate and gonadotropin resistant. Effects of pre-transplant L-carnitine supplementation on primary graft dysfunction in liver transplant recipients: a pilot, randomized, placebo-controlled clinical trial. Multiple studies have shown that when used, L-carnitine can help reduce the high blood pressure, which along with oxidative stress, serves as one of the main risk factors for heart disease, thus reducing the risk of this horrifying disease and improving the patients' heart health. JPEN J Parenter.Enteral Nutr. Phase IIb multicentred randomised trial of besifovir (LB80380) versus entecavir in Asian patients with chronic hepatitis B. Fertil.Steril 2003;80(Suppl 3):48. Weschler, A., Aviram, M., Levin, M., Better, O. S., and Brook, J. G. High dose of L-carnitine increases platelet aggregation and plasma triglyceride levels in uremic patients on hemodialysis. Kahn J, Lagakos S, Wulfsohn M, et al. Cellular stress responses, mitostress and carnitine insufficiencies as critical determinants in aging and neurodegenerative disorders: role of hormesis and vitagenes. Jpn Heart J 1995;36(3):319-331. In cells, it helps transport fatty acids into the mitochondria, where they can be burned for energy. Am J Dis Child 1991;145:999-1001. Nephron 55 (1990): 28-32. Youle, M. and Osio, M. A double-blind, parallel-group, placebo-controlled, multicentre study of acetyl L-carnitine in the symptomatic treatment of antiretroviral toxic neuropathy in patients with HIV-1 infection. View abstract. View abstract. View abstract. Swart I, Rossouw J, Loots JM, and et al. View abstract. The effect of L-carnitine supplement on dialysis patients [abstract]. View abstract. Fertil Steril 2002;78:1203-8.. View abstract. J.HainanMed.College 2011;17(3):347-349. However, L-carnitine supplements may raise your blood levels of trimethylamine-N-oxide (TMAO) over time. Neurologia 2007;22(5):329-332. Am J Clin Nutr 1989;49(2):283-289. J Neurol.Sci 3-15-2004;218(1-2):103-108. Wu, Z. M., Lu, X., Wang, Y. W., Sun, J., Tao, J. W., Yin, F. H., and Cheng, H. J. Some animal studies suggest that the acetyl form, acetyl-L-carnitine (ALCAR), may help prevent age-related mental decline and improve markers of learning (30, 31). View abstract. J Pediatr 1982;101:782-5. View abstract. 2007;110(2 Pt 2):480-482. View abstract. Samimi M, Jamilian M, Ebrahimi FA, Rahimi M, Tajbakhsh B, Asemi Z. Some dosage forms listed on this page may not apply to the brand name L-Carnitine. Calabrese, V., Cornelius, C., Stella, A. M., and Calabrese, E. J. L-Carnosine is known as the ' longevity molecule'. Jing, L., Zhou, L. J., Li, W. M., Zhang, F. M., Yuan, L., Li, S., Song, J., and Sang, Y. Carnitine regulates myocardial metabolism by Peroxisome Proliferator-Activated Receptor-alpha (PPARalpha) in alcoholic cardiomyopathy. Rare side effects can include muscle weakness in uremic patients and seizures in people with seizure disorders. Pichard, C., Roulet, M., Schutz, Y., Rossle, C., Chiolero, R., Temler, E., Schindler, C., Zurlo, F., Furst, P., and Jequier, E. Clinical relevance of L-carnitine-supplemented total parenteral nutrition in postoperative trauma. Mantovani, G. Randomised phase III clinical trial of 5 different arms of treatment on 332 patients with cancer cachexia. Preliminary report. Arq Bras.Endocrinol.Metabol. Caruso U, Leone L Cravotto E Nava D. Effects of L-carnitine on anemia in aged hemodialysis patients treated with recombinant human erythropoietin: A pilot study. L-carnitine supplementation vs cycle ergometer exercise for physical activity and muscle status in hemodialysis patients: a randomized clinical trial. View abstract. Follow all directions on your prescription label. Skip the missed dose if it is almost time for your next scheduled dose. 2008;8:365. Trovato GM, Ginardi V, Di Marco V, and et al. Supplements may also benefit those with lower levels, such as older adults, vegans and vegetarians. Int J Cardiol 1992;34(2):167-172. The highest concentrations are in high energy demand areas such as your brain, heart and muscles. 2010;30(4):233-239. View abstract. Life Sci 1996;59:1579-99. Kang, H. C., Kim, H. D., Lee, Y. M., and Han, S. H. Landau-Kleffner syndrome with mitochondrial respiratory chain-complex I deficiency. BMC Cardiovasc Disord. Cancer Biol.Ther 7-15-2011;12(2):125-130. Nat Med. View abstract. View abstract. Lee, M. S., Lee, H. J., Lee, H. S., and Kim, Y. L-carnitine stimulates lipolysis via induction of the lipolytic gene expression and suppression of the adipogenic gene expression in 3T3-L1 adipocytes. insomnia numbness in feet or hands Call your doctor if any of these symptoms persist, or if they get worse. Eur Heart J 1992;13:251-5. View abstract. [The anti-arrhythmic effect of L-carnitine in subjects with ischemic cardiopathy]. J Med.Food 2006;9(4):468-473. Basic Clin Pharmacol Toxicol. G.Ital.Cardiol. 2008;15(8):595-601. Use of a long-chain triglyceride-restricted/medium-chain triglyceride-supplemented diet in a case of malonyl-CoA decarboxylase deficiency with cardiomyopathy. Hirose S, Mitsudome A, Yasumoto S, et al. Loffredo, L., Pignatelli, P., Cangemi, R., Andreozzi, P., Panico, M. A., Meloni, V., and Violi, F. Imbalance between nitric oxide generation and oxidative stress in patients with peripheral arterial disease: effect of an antioxidant treatment. Effect of L-carnitine supplementation on renal anemia in patients on hemodialysis: a meta-analysis. Mov Disord. 2010;13(2-3):148-151. Ramos AC, Barrucand L, Elias PR, et al. View abstract. J Nephrol. The effect of levocarnitine for plasmatic matrix metalloproteinases (MMPS) on acute cerebral infarct patients. Side Effects. Cucinotta D, Passeri M, Ventura S, and et al. Korean J Gastroenterol. You may report side effects to FDA at 1-800-FDA-1088. Ma, S. J., Cai, W. W., and Sheng, J. View abstract. Effects of Citric Acid and l-Carnitine on Physical Fatigue. Turpeinen, A. K., Kuikka, J. T., Vanninen, E., Yang, J., and Uusitupa, M. I. Controlled study on the therapeutic efficacy of propionyl-L-carnitine in patients with congestive heart failure. Adding L-carnitine to clomiphene resistant PCOS women improves the quality of ovulation and the pregnancy rate. View abstract. Drugs Exp Clin Res 1995;21(4):157-159. View abstract. Current Therapeutic Research 1981;30(5):753-764. Clin Ter. (More information) If you choose to take L-carnitine supplements, the Linus Pauling Institute recommends acetyl-L-carnitine at a daily dose of 0.5 to 1 g. View abstract. 2004;97(2):c41-c48. View abstract. Effects of L-carnitine administration on left ventricular remodeling after acute anterior myocardial infarction: the L-Carnitine Ecocardiografia Digitalizzata Infarto Miocardico (CEDIM) Trial. Preliminary observations on the use of propionyl-L-carnitine in combination with sildenafil in patients with erectile dysfunction and diabetes. View abstract. Salonia, A. Prog Retin Eye Res. J Pain Symptom.Manage. Comparison of vitamin E and propionyl-L-carnitine, separately or in combination, in patients with early chronic Peyronie's disease: a double-blind, placebo controlled, randomized study. Although potent on its own, this supplement works best when stacked with other nootropics. Eur J Appl Physiol 2005;95(5-6):431-435. Hum.Exp.Toxicol. Brunel-Guitton, C., Costa, T., Mitchell, G. A., and Lambert, M. Treatment of cobalamin C (cblC) deficiency during pregnancy. Ann.Pharmacother. Watanabe, S., Ajisaka, R., Masuoka, T., Yamanouchi, T., Saitou, T., Toyama, M., Takeyasu, N., Sakamoto, K., and Sugishita, Y. Neuromuscul.Disord. Brevetti G, Perna S, Sabba C, et al. Eur.Neuropsychopharmacol. We comply with the HONcode standard for trustworthy health information. View abstract. J Neuropsychiatry Clin Neurosci. 2008;54(6):375-381. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. eCollection 2019. Russell, S. Carnitine as an antidote for acute valproate toxicity in children. Ann.Indian Acad.Neurol. G Ital Cardiol 1983;13(11):291-294. J Pediatr 1983;102:931-5. Several conditions can cause bradycardia, including several potentially serious conditions, such as myocarditis, sleep apnea, lupus or certain medications. J Child Neurol 2003;18:552-4. View abstract. 2009;79(3):131-141. L-carnitine is a nutrient and dietary supplement. B., and Wang, Y. X. This includes older adults and people who rarely or never eat meat and fish. Int.J Cardiol. Minerva Cardioangiol. 2006;7(2):101-109. Eggs are so nutritious that they're often referred to as "nature's multivitamin." Arch Dis.Child Fetal Neonatal Ed 1998;78(3):F185-F188. View abstract. L-carnitine and platelet aggregation in uremic patients subjected to hemodialysis. Hauck, E. W., Diemer, T., Schmelz, H. U., and Weidner, W. A critical analysis of nonsurgical treatment of Peyronie's disease. 2009;6:9. View abstract. Dial Transplant 1998;27:498-506. Reduce dosage to alleviate this side effect. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. View abstract. Am J Dis Child 1987;141:660-5. Chen, X. F., Li, Z., Ping, P., Dai, J. C., Zhang, F. B., and Shang, X. J. The effect of (L-)carnitine on weight loss in adults: a systematic review and meta-analysis of randomized controlled trials. 2009;156(1):161-171. Changes in physical performance of untrained volunteers: effects of L-carnitine. This article explains why some people have a fast metabolism and how you can speed up yours to burn more calories. Jpn Circ.J 1992;56(1):86-94. I take alpha lipoic acid and acetyl L carnitine twice a day, everyday. View abstract. View abstract. View abstract. Effect of carni Q-gel (ubiquinol and carnitine) on cytokines in patients with heart failure in the Tishcon study. Caponnetto S, Canale C, Masperone MA, et al. Bjornsson, E. Hepatotoxicity associated with antiepileptic drugs. Hsieh, C. T., Hwu, W. L., Huang, Y. T., Huang, A. C., Wang, S. F., Hu, M. H., and Chien, Y. H. Early detection of glutaric aciduria type I by newborn screening in Taiwan. View abstract. View abstract. 2009;9:53. View abstract. L-arginine should be used with caution. View abstract. Krahenbuhl S, Reichen J. Carnitine metabolism in patients with chronic liver disease. 2011;55(8):1022-1028. 2013;32(1):41-9. Arch Intern Med 1999;159:1143-4. Jirillo, E., Altamura, M., Munno, I., Pellegrino, N. M., Sabato, R., Di Fabio, S., and De Simone, C. Effects of acetyl-L-carnitine oral administration on lymphocyte antibacterial activity and TNF-alpha levels in patients with active pulmonary tuberculosis. Gynecol Endocrinol 2019;35(8):701-5. doi: 10.1080/09513590.2019.1576622. Sirtori, C. R., Calabresi, L., Ferrara, S., Pazzucconi, F., Bondioli, A., Baldassarre, D., Birreci, A., and Koverech, A. L-carnitine reduces plasma lipoprotein(a) levels in patients with hyper Lp(a). Jing, L., Li, W. M., Zhou, L. J., and Song, J. 2009;19(3):212-216. Scarpini E, Sacilotto G, Baron P, et al. View abstract. It is unlikely to cause significant weight loss. J Am Coll Cardiol 1995;26:380-7. J Am.Board Fam.Med. Clin Hemorheol.Microcirc. J Am Coll Cardiol 1995;26:1411-6. Gunal, A. I., Celiker, H., Donder, E., and Gunal, S. Y. 2007;62(4):349-354. Hiatt, W. R., Creager, M. A., Amato, A., and Brass, E. P. Effect of propionyl-L-carnitine on a background of monitored exercise in patients with claudication secondary to peripheral artery disease. View abstract. 2011;28(4):393-400. L-Carnitine may cause serious side effects. View abstract. Am J Ther. 1990;5(3):263-265. Prohaska ES, Muzyk AJ, Rivelli SK. View abstract. Cavallini G, Biagiotti G, Koverech A, Vitali G. Oral propionyl-l-carnitine and intraplaque verapamil in the therapy of advanced and resistant Peyronie's disease. View abstract. Metabolism 2009;58(11):1618-1623. 11 Best Foods to Boost Your Brain and Memory, The 10 Best Nootropic Supplements to Boost Brain Power, How to Speed Up Your Metabolism: 9 Easy Ways Backed by Science, 18 Popular Weight Loss Medications and Supplements Reviewed, 6 Reasons Why Eggs Are the Healthiest Food on the Planet, Fast Metabolism 101: What It Is and How to Get It. 12-3-1999;87(4):366-368. Katiyar, A. and Aaron, C. Case files of the Children's Hospital of Michigan Regional Poison Control Center: the use of carnitine for the management of acute valproic acid toxicity. Guideri, F., Acampa, M., Hayek, Y., and Zappella, M. Effects of acetyl-L-carnitine on cardiac dysautonomia in Rett syndrome: prevention of sudden death? View abstract. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Ma, Y. Y., Song, J. Q., Wu, T. F., Liu, Y. P., Xiao, J. X., Jiang, Y. W., and Yang, Y. L. [Leucodystrophy induced by late onset 3-hydroxy-3-methylglutaric aciduria]. Malaguarnera, M., Gargante, M. P., Cristaldi, E., Vacante, M., Risino, C., Cammalleri, L., Pennisi, G., and Rampello, L. Acetyl-L-carnitine treatment in minimal hepatic encephalopathy. View abstract. Of the different forms, acetyl-L-carnitine and L-carnitine are the most popular and seem to be most effective. Seong, S. H., Cho, S. C., Park, Y., and Cha, Y. S. L-carnitine-supplemented parenteral nutrition improves fat metabolism but fails to support compensatory growth in premature Korean infants. View abstract. J Clin Biochem.Nutr. An JH, Kim YJ, Kim KJ, et al. L-carnitine specifically acetyl-L-carnitine can have beneficial effects on brain function in various diseases. Schiavoni, G., Lucente, M., Di Folca, A., Alessandri, N., Mongiardo, R., and Manzoli, U. Hum.Reprod. It can also cause the urine, breath, and sweat to have a "fishy" odor. View abstract. Mild myasthenia has occurred in uremic patients receiving D,L-carnitine (but not levocarnitine). View abstract. Written by Cerner Multum. View abstract. Jacobs, P. L., Goldstein, E. R., Blackburn, W., Orem, I., and Hughes, J. J. Glycine propionyl-L-carnitine produces enhanced anaerobic work capacity with reduced lactate accumulation in resistance trained males. Acta Neurol.Taiwan. Biomed Pharmacother. Rev.Neurol. View abstract. View abstract. A. 2008;26(3):388-4. Riva R, Albani F, Gobbi G, et al. View abstract. Mult Scler 2006;12:321-4. Kor J Nephrol 1992;11:260-269. View abstract. Rebuzzi AG, Schiavani G, Amico C, and et al. [Chronic fatigue syndrome and neurotransmitters]. View abstract. Swiss Med Wkly 2004;134:385. View abstract. View abstract. View abstract. However, on account of strict homeostatic regulation of plasma L-carnitine concentrations, higher doses of L-carnitine supplementation may not provide additional therapeutic benefits. 2013;38(1):31-41. How Much Caffeine Is Okay? Stuessi, C., Hofer, P., Meier, C., and Boutellier, U. L -Carnitine and the recovery from exhaustive endurance exercise: a randomised, double-blind, placebo-controlled trial. L-carnitine can absolutely cause heart disease - but only if you have the gut microbes needed to break it down, he said. Graziano F, Bisonni R, Catalano V, et al. Iyer, R. N., Khan, A. 2006;49(6):987-997. Ann N.Y.Acad.Sci 2004;1033:168-176. Karl M, Rubenstein M, Rudnick C, Brejda J. View abstract. Prolonged oral L-carnitine substitution increases bicycle ergometer performance in patients with severe, ischemically induced cardiac insufficiency. Agarwal A, Sengupta P, Durairajanayagam D. Role of L-carnitine in female infertility. Van Oudheusden, L. J. and Scholte, H. R. Efficacy of carnitine in the treatment of children with attention-deficit hyperactivity disorder. If you happen to feel nausea, next time just take this supplement with food or take a lesser dose. Clin Drug Invest 1996;11(2):90-96. Askarpour M, Hadi A, Miraghajani M, Symonds ME, Sheikhi A, Ghaedi E. Beneficial effects of l-carnitine supplementation for weight management in overweight and obese adults: An updated systematic review and dose-response meta-analysis of randomized controlled trials. Obstet.Gynecol. Clin Chim Acta 1982;122:369-75. Chan, A., Paskavitz, J., Remington, R., Rasmussen, S., and Shea, T. B. Efficacy of a vitamin/nutriceutical formulation for early-stage Alzheimer's disease: a 1-year, open-label pilot study with an 16-month caregiver extension. Taking your CoQ10 with food not only helps . Kotby, A. View abstract. Gastrointestinal 2016;39(6):277-80.View abstract. 2012;13(2):285-293. Bellinghieri G, Savica V, Barbera CM, Ricciardi B, Egitto M, Torre F, Valentini G, D'Iddio S, Bagiella E, Mallamace A, et al. Bellinghieri, G., Savica, V., Mallamace, A., Di, Stefano C., Consolo, F., Spagnoli, L. G., Villaschi, S., Palmieri, G., Corsi, M., and Maccari, F. Correlation between increased serum and tissue L-carnitine levels and improved muscle symptoms in hemodialyzed patients. Hypertension 2009;54(3):567-574. 12-20-2008;23(6):571-585. Calabrese, V., Giuffrida Stella, A. M., Calvani, M., and Butterfield, D. A. Acetylcarnitine and cellular stress response: roles in nutritional redox homeostasis and regulation of longevity genes. ALCAR might do the same, but studies haven't confirmed this [95, 96, 97]. Diabetologia 1997;40(1):A32. Arzneimittelforschung 1982;32(3):293-297. Arch.Pediatr 2012;19(2):184-193. View abstract. Lim, C. Y., Jun, D. W., Jang, S. S., Cho, W. K., Chae, J. D., and Jun, J. H. Effects of carnitine on peripheral blood mitochondrial DNA copy number and liver function in non-alcoholic fatty liver disease. Disclaimer: Go To See My Account. A randomized controlled trial. Footitt, E. J., Stafford, J., Dixon, M., Burch, M., Jakobs, C., Salomons, G. S., and Cleary, M. A. Wang Y, Xu Y, Zou R, et al. 2013 Nov;30(8):742-7. View abstract. Reuter, S. E. and Evans, A. M. Long-chain acylcarnitine deficiency in patients with chronic fatigue syndrome. Sloan, R. S., Kastan, B., Rice, S. I., Sallee, C. W., Yuenger, N. J., Smith, B., Ward, R. A., Brier, M. E., and Golper, T. A. J Assoc Physicians India 2000;48(11):1050-1052. This article lists 5 natural fat burners that are supported by science. It may also combat diabetes by increasing a key enzyme called AMPK, which improves your bodys ability to use carbs (56). Your L-carnitine levels are influenced by how much youre eating and how much your body is producing. Trappe, S. W., Costill, D. L., Goodpaster, B., Vukovich, M. D., and Fink, W. J. The effects of L-carnitine supplementation on performance during interval swimming. 2008;47(11):934-937. View abstract. Hakeshzadeh, F., Tabibi, H., Ahmadinejad, M., Malakoutian, T., and Hedayati, M. Effects of L-Carnitine supplement on plasma coagulation and anticoagulation factors in hemodialysis patients. View abstract. 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BJU Int 2002;89:895-900. Diabetes Res.Clin Pract. J Pharmacol Exp Ther 1999;290:1482-92. Int J Clin Pharmacol Res 1990;10:355-60. Cuturic, M., Abramson, R. K., Moran, R. R., and Hardin, J. W. Clinical outcomes and low-dose levocarnitine supplementation in psychiatric inpatients with documented hypocarnitinemia: a retrospective chart review. View abstract. View abstract. View abstract. Crill, C. M., Storm, M. C., Christensen, M. L., Hankins, C. T., Bruce, Jenkins M., and Helms, R. A. Carnitine supplementation in premature neonates: effect on plasma and red blood cell total carnitine concentrations, nutrition parameters and morbidity. A Meta-Analysis of the Efficacy of L-Carnitine/L-Acetyl-Carnitine or N-Acetyl-Cysteine in Men With Idiopathic Asthenozoospermia. A pilot study on aging skeletal muscle mass and function. These symptoms are not considered to be severe side effects. Because carnosine can lower blood pressure, individuals with already low blood pressure should exercise extra caution when taking it . pii: E255. Effects of L-carnitine supplementation in patients receiving hemodialysis or peritoneal dialysis. View abstract. View abstract. A double-blind randomized study. One 12-month study observed a reduction in heart failure and deaths among participants who took L-carnitine supplements (42). Bartels GL, Remme WJ, den Hartog FR, et al. Reported side effects are unusual, but include insomnia, headache, diarrhea, low or high blood pressure, nausea, blurred vision, and chest pains. 2012;4:CD006282. 2011;17(6):I15-I23. 2013 Apr;121(4):234-8. To determine the dose and tolerability we conducted a phase II study with increasing doses of L-carnitine supplementation. Tumori 2005;91(2):135-138. Physiologie. Sole MJ, Jeejeebhoy KN. Blood 1998;91:3817-24. Rajasekar, P. and Anuradha, C. V. L-Carnitine inhibits protein glycation in vitro and in vivo: evidence for a role in diabetic management. View abstract. Coulter DL. View abstract. Store at room temperature away from moisture and heat. I. Carnitine concentrations and lipid effects." Int J Clin Pharmacol Res 1983;3(3):179-184. European multicenter study on propionyl-L-carnitine in intermittent claudication. The dose of your acenocoumarol might need to be changed.